9 In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels

Author(s): Karadag, E; Saraydin, D; Cetinkaya, S; Guven, O

Title: In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels

Source: BIOMATERIALS, 17 (1): 67-70 JAN 1996

Language: English

Document Type: Article

Author Keywords: hydrogels; acrylamide-based hydrogels; swelling; human serum; biocompatibility

Abstract: In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution-and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are incubated in 10 different human sera for 24 h and their biocompatibilities with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide/crotonic and acrylamide/itaconic acid hydrogels are biocompatible.

Addresses: CUMHURIYET UNIV,FAC MED,SIVAS 58140,TURKEY; HACETTEPE UNIV,DEPT CHEM,ANKARA 06532,TURKEY

Reprint Address: Karadag, E, CUMHURIYET UNIV,DEPT CHEM,SIVAS 58140,TURKEY.

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Cited Reference Count: 14

Times Cited: 49

Publisher: ELSEVIER SCI LTD

Publisher Address: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB

ISSN: 0142-9612

29-char Source Abbrev.: BIOMATERIALS

ISO Source Abbrev.: Biomaterials

Source Item Page Count: 4

Subject Category: ENGINEERING, BIOMEDICAL; MATERIALS SCIENCE, BIOMATERIALS

ISI Document Delivery No.: TY457