31 In vitro dynamic swelling behaviors of polyhydroxamic acid hydrogels in the simulated physiological body fluids

Author(s): Saraydin, D; Caldiran, Y

Title: In vitro dynamic swelling behaviors of polyhydroxamic acid hydrogels in the simulated physiological body fluids

Source: POLYMER BULLETIN, 46 (1): 91-98 FEB 2001

Language: English

Document Type: Article

Keywords Plus: BOVINE SERUM-ALBUMIN; AMINO-ACIDS; COPOLYMERS; WATER; ADSORPTION; BIOCOMPATIBILITY; ACRYLATE; SOLUTE

Abstract: Influence of some simulated physiological body fluids on the dynamic swelling behaviour of polyelectrolytic hydroxamic acid hydrogels (PHA) was investigated at 37 degreesC in vitro. The simulated physiological body fluids are distilled water, human sera, physiological saline (0.89% NaCl), isoosmotic phosphate buffer at pH 7.4, gastric fluid at pH 1.1, (gylicine-HCl buffer), urea (0.3 mol L-1), and the aquatic solutions of K2HPO4 and KNO3 (the sources of K+). The values of equilibrium swelling of PHA hydrogels varied in the range of 130-4625%, while the values of equilibrium fluid content of the hydrogels varied in the range of 57-97%. The initial rate of swelling, diffusional exponent, and, diffusion coefficient were calculated using swelling kinetics data. Diffusion of the fluids into the hydrogel was found to be non-Fickian character. The diffusion coefficients of the hydrogel varied between 0.6x10(-6) - 8.1x10(-6) cm(2) s(-1).

Addresses: Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey

Reprint Address: Saraydin, D, Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey.

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Cited Reference Count: 23

Times Cited: 3

Publisher: SPRINGER-VERLAG

Publisher Address: 175 FIFTH AVE, NEW YORK, NY 10010 USA

ISSN: 0170-0839

29-char Source Abbrev.: POLYM BULL

ISO Source Abbrev.: Polym. Bull.

Source Item Page Count: 8

Subject Category: POLYMER SCIENCE

ISI Document Delivery No.: 409UW