33 In vivo biocompatibility of radiation induced acrylamide and acrylamide/maleic acid hydrogels

Author(s): Saraydin, D; Koptagel, E; Unver-Saraydin, S; Karadag, E; Guven, O

Title: In vivo biocompatibility of radiation induced acrylamide and acrylamide/maleic acid hydrogels

Source: JOURNAL OF MATERIALS SCIENCE, 36 (10): 2473-2481 2001

Language: English

Document Type: Article

Keywords Plus: BOVINE SERUM-ALBUMIN; BIOMEDICAL APPLICATIONS; COPOLYMERIC HYDROGELS; CROSSLINKED HYDROGELS; SWELLING BEHAVIOR; FUNCTIONAL-GROUPS; CELL BEHAVIOR; RELEASE; ADSORPTION; BIOMATERIALS

Abstract: In vitro swelling and in vivo biocompatibility of radiation induced acrylamide (AAm) and acrylamide/maleic acid (AAm/MA) hydrogels were investigated. The swelling kinetics of AAm and AAm/MA hydrogels of are investigated in distilled water, human serum and some simulated physiological fluids such as phosphate buffer at pH 7.4, glycine-HCl buffer at pH 1.1, physiological saline solution and, some swelling and diffusion parameters have been calculated. AAm and AAm/MA hydrogels were subcutaneously implanted in rats for up to 10 weeks and the tissue response to these implants was studied. Histological analysis indicated that tissue reaction at the implant site progressed from an initial acute inflammatory response characterized. No necrosis, tumorigenesis or infection was observed at the implant site up to 10 week. In vivo studies indicated that the radiation induced acrylamide and acrylamide/maleic acid hydrogels were found to be well-tolerated, non-toxic and highly biocompatible. (C) 2001 Kluwer Academic Publishers.

Addresses: Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey; Cumhuriyet Univ, Fac Med, Dept Histol Embryol, TR-58140 Sivas, Turkey; Adnan Menderes Univ, Dept Chem, TR-09010 Aydin, Turkey; Hacettepe Univ, Dept Chem, TR-06532 Ankara, Turkey

Reprint Address: Saraydin, D, Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey.

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Cited Reference Count: 45

Times Cited: 6

Publisher: KLUWER ACADEMIC PUBL

Publisher Address: SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS

ISSN: 0022-2461

29-char Source Abbrev.: J MATER SCI

ISO Source Abbrev.: J. Mater. Sci.

Source Item Page Count: 9

Subject Category: MATERIALS SCIENCE, MULTIDISCIPLINARY

ISI Document Delivery No.: 428MK