54 Synthesis, characterization and evaluation of IPN hydrogels for antibiotic release

Author(s): Ekici, S; Saraydin, D

Title: Synthesis, characterization and evaluation of IPN hydrogels for antibiotic release

Source: DRUG DELIVERY, 11 (6): 381-388 NOV-DEC 2004

Language: English

Document Type: Article

Author Keywords: amoxicillin; chitosan; drug release; hydrogel; interpenetrating polymeric networks

Keywords Plus: IN-VITRO; POLY(ACRYLIC ACID); DELIVERY-SYSTEMS; DRUG-DELIVERY; CHITOSAN; BIOCOMPATIBILITY; NETWORKS; COMPLEXATION

Abstract: We prepared new ternary interpenetrating polymeric networks (IPN) systems containing chitosan, poly(N-vinylpyrrolidone) and poly(acrylamide) polymers. IPNs were synthesized by radical polymerization of acrylamide monomers in presence of glutaraldehyde (G) and N,N'-methylenebisacrylamide as crosslinkers and the other polymers. These IPNs were named as C-P-A. Glutaraldehyde were used in different concentration to control the network porous of IPNs. Spectroscopic and thermal analyses of these cylindrical shaped IPNs were made with fourier transform infrared spectroscopy analysis, thermogravimetric analysis, and thermomechanical analysis. Swelling studies of IPNs were carried out at pH 1.1 and pH 7.4 at 37degreesC. The swelling and diffusion parameters of IPNs in these solutions were calculated. Amoxicillin as a bioactive species was entrapped to the IPNs during synthesis. In vitro release kinetics of IPNs were investigated. The experimental data of swelling and release studies suggest clearly that the swelling and release process obeys second-order kinetics. The release of the entrapped bioactive species from IPNs depends on the degree of crosslinking of the polymer and pH of the medium at body temperature. We observed that amoxicillin release at pH 1.1 was higher than at pH 7.4. As a result, IPNs-based chitosan with different cross-linker concentration could be promising candidates for formulation in oral gastrointestinal delivery systems.

Addresses: Onsekiz Mart Univ, Dept Chem, TR-17020 Canakkale, Turkey; Cumhuriyet Univ, Dept Chem, Hydrogel Res Lab, Sivas, Turkey

Reprint Address: Ekici, S, Onsekiz Mart Univ, Dept Chem, TR-17020 Canakkale, Turkey.

E-mail Address: sekici@comu.edu.tr

Cited References: AHN JS, 2002, BIOMATERIALS, V23, P1411.
BAJPAI AK, 2001, REACT FUNCT POLYM, V50, P9.
BAJPAI AK, 2002, REACT FUNCT POLYM, V53, P125.
CHAKRABARTY D, 1998, POLYM GELS NETW, V6, P191.
CHANGEZ M, 2003, BIOMATERIALS, V24, P527.
DELATORRE PM, 2003, BIOMATERIALS, V24, P1499.
EKICI S, 2003, ADSORPT SCI TECHNOL, V21, P651.
ELVIRA C, 2002, BIOMATERIALS, V23, P1955.
GERESH S, 2004, J CONTROL RELEASE, V94, P391.
HEJAZI R, 2003, J CONTROL RELEASE, V89, P151.
KARADAG E, 1996, BIOMATERIALS, V17, P67.
KATIME I, 2001, POLYM INT, V50, P869.
KHALID MN, 2002, EUR J PHARM SCI, V15, P425.
KOSEVA N, 1999, POLYM BULL, V43, P101.
KOSMALA JD, 2000, BIOMATERIALS, V21, P2019.
LAU C, 2002, POLYMER, V43, P823.
OZTOP HN, 2002, APPL BIOCHEM BIOTECH, V101, P239.
PENICHE C, 1999, BIOMATERIALS, V20, P1869.
PEPPAS NA, 2000, ANNU REV BIOMED ENG, V2, P9.
PEPPAS NA, 2000, EUR J PHARM BIOPHARM, V50, P27.
RISBUD MV, 2000, DRUG DELIV, V7, P69.
SARAYDIN D, 1995, RADIAT PHYS CHEM, V46, P1049.
SOPPIRNATH KS, 2002, EUR J PHARM BIOPHARM, V53, P87.

Cited Reference Count: 23

Times Cited: 0

Publisher: TAYLOR & FRANCIS INC

Publisher Address: 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA

ISSN: 1071-7544

29-char Source Abbrev.: DRUG DELIV

ISO Source Abbrev.: Drug Deliv.

Source Item Page Count: 8

Subject Category: PHARMACOLOGY & PHARMACY

ISI Document Delivery No.: 877LK