56 Dynamic swelling behavior of gamma-radiation induced polyelectrolyte poly(AAm-co-CA) hydrogels in urea solutions

Author(s): Karadag, E; Uzum, OB; Saraydin, D; Guven, O

Title: Dynamic swelling behavior of gamma-radiation induced polyelectrolyte poly(AAm-co-CA) hydrogels in urea solutions

Source: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 301 (1-2): 102-111 SEP 14 2005

Language: English

Document Type: Article

Author Keywords: gamma-radiation; swelling; diffusion; acrylamide/crotonic acid; hydrogel; urea

Keywords Plus: BIOMEDICAL APPLICATIONS; AQUEOUS-SOLUTION; ACID) HYDROGELS; DRUG-DELIVERY; POLYMERS; RELEASE; COPOLYMERS

Abstract: The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obtained in the form of rods after radiation. Swelling experiments were performed in aqueous urea solutions at 25 degrees C, gravimetrically. The hydrogels showed large extents of swelling in aqueous (urea/water) media the swelling being highly dependent on the chemical composition of the hydrogels and irradiation dose. The percentage swelling of poly(AAm-co-CA) hydrogels was between 1160 and 4250%, while that of the AAm hydrogels was between 670 and 900%. The diffusional exponent values (it) are between 0.51 and 0.66, hence the diffusion of urea/water into the hydrogels is non-Fickian. Equilibrium urea/water contents of the hydrogel systems were changed between 0.870 and 0.977. (C) 2005 Elsevier B.V. All rights reserved.

Addresses: Adnan Menderes Univ, Fen Edebiyat Fac, Dept Chem, TR-09010 Aydin, Turkey; Cumhuriyet Univ, Dept Chem, TR-58140 Sivas, Turkey; Hacettepe Univ, Dept Chem, TR-06532 Beytepe, Turkey

Reprint Address: Karadag, E, Adnan Menderes Univ, Fen Edebiyat Fac, Dept Chem, TR-09010 Aydin, Turkey.

E-mail Address: ekaradag@adu.edu.tr

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Cited Reference Count: 36

Times Cited: 0

Publisher: ELSEVIER SCIENCE BV

Publisher Address: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS

ISSN: 0378-5173

29-char Source Abbrev.: INT J PHARM

ISO Source Abbrev.: Int. J. Pharm.

Source Item Page Count: 10

Subject Category: Pharmacology & Pharmacy

ISI Document Delivery No.: 969MS