62 Interpenetrating polymeric network hydrogels for potential gastrointestinal drug release

Author(s): Ekici S (Ekici, Sema), Saraydin D (Saraydin, Dursun)
Title: Interpenetrating polymeric network hydrogels for potential gastrointestinal drug release
Source:  : POLYMER INTERNATIONAL  56 (11): 1371-1377 NOV 2007
Language: English
Document Type: Article
Author Keywords: IPN hydrogels; drug release; pH-sensitive release; amoxicillin; poly(acrylic acid)
Keywords Plus: POLY(ACRYLIC ACID); CHITOSAN; COMPLEXATION; DELIVERY

Abstract: New interpenetrating polymeric network (IPN) hydrogels based on chitosan (C), poly(N-vinyl pyrrolidone) (PVP) and poly(acrylic acid) (PAAc), crosslinked with glutaraldchyde (G) and N,N'-methylenebisacrylamide (MBA), were prepared and investigated for potential gastrointestinal drug delivery vehicles utilizing a model drug, amoxicillin. IPN hydrogels were synthesized by simultaneous polymerization/crosslinking of acrylic acid monomer in the presence of another polymer (C) and crosslinker (G, MBA). Three different concentrations of glutaraldehyde were used (0.5, 1.0 and 2.0 w/w) to control the overall porosity of the hydrogels, named C-P-AAc/0.5, C-P-AAc/1.0 and C-P-AAc/2.0, respectively. Spectroscopic and thermal analyses such as Fourier transform infrared spectroscopy, thermogravimetric analysis and thermornechanical analysis were performed for IPN characterization. Equilibrium swelling studies were conducted for pH and temperature response behavior. Swelling studies were also carried out in simulated gastric fluid of pH = 1.1 and simulated intestinal fluid of pH = 7.4 to investigate possible site-specific drug delivery. It was found that the release behavior of the drug from these IPN hydrogels was dependent on the pH of the medium and the proportion of crosslinker in the IPN. It was observed that amoxicillin release at pH = 7.4 was higher than at pH = 1.1. The analysis of the drug release showed that amoxicillin was released from these hydrogels through a non-Fickian diffusion mechanism. (c) 2007 Society of Chemical Industry.

Addresses: 1. Canakkale Onsekiz Mart Univ, Dept Chem, TR-17020 Canakkale, Turkey 2. Cumhuriyet Univ, Dept Chem, Hydrogel Res Lab, Sivas, Turkey
Reprint Address: Ekici, S (reprint author), Canakkale Onsekiz Mart Univ, Dept Chem, Terzioglu Campus, TR-17020 Canakkale, Turkey
E-mail Address: sekici@comu.edu.tr
Cited References:
BAJPAI AK Release and diffusion of sulfamethoxazole through acrylamide-based hydrogel
JOURNAL OF APPLIED POLYMER SCIENCE 81 : 1238 2001

CHANGEZ M The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro BIOMATERIALS 24 : 527 2003

DELATORRE PM Release of amoxicillin from polyionic complexes of chitosan and poly(acrylic acid). study of polymer/polymer and polymer/drug interactions within the network structure
BIOMATERIALS 24 : 1499 2003

EKICI S Adsorption of some textile dyes onto crosslinked poly(N-vinylpyrrolidone)
ADSORPTION SCIENCE & TECHNOLOGY 21 : 651 2003

EKICI S Synthesis, characterization and evaluation of IPN hydrogels for antibiotic release
DRUG DELIVERY 11 : 381 DOI 10.1080/10717540490884804 2004

GERESH S Bioadhesive grafted starch copolymers as platforms for peroral drug delivery: a study of theophylline release JOURNAL OF CONTROLLED RELEASE 94 : 391 DOI 10.1016/j.jconrel.2003.10.019 2004

HEJAZI R Chitosan-based gastrointestinal delivery systems  JOURNAL OF CONTROLLED RELEASE 89 : 151 DOI 10.1016/S0168-3659(03)00126-3 2003

HU Y Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles  BIOMATERIALS 23 : 3193 2002

KHALID MN Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 15 : 425 2002

KOSEVA N Chitosan gel beads as drug carriers 2. Release of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 2,5-dihydroxybenzenesulfonic acid  POLYMER BULLETIN 43 : 101 1999

KOSMALA JD Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials  BIOMATERIALS 21 : 2019 2000

LAU C A study of blending and complexation of poly(acrylic acid)/poly(vinyl pyrrolidone)
POLYMER 43 : 823 2002

LEE YM Synthesis and swelling characteristics of pH and thermoresponsive interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and poly(acrylic acid)
JOURNAL OF APPLIED POLYMER SCIENCE 62 : 301 1996

PENICHE C Self-curing membranes of chitosan/PAA IPNs obtained by radical polymerization: preparation, characterization and interpolymer complexation  BIOMATERIALS 20 : 1869 1999

PEPPAS NA Hydrogels in pharmaceutical formulations  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 50 : 27 2000

SOPPIRNATH KS Water transport and drug release study from cross-linked polyacrylamide grafted guar gum hydrogel microspheres for the controlled release application  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 53 : 87 2002

WU KH FTIR and TGA studies of poly(4-vinylpyridine-co-divinylbenzene)-Cu(II) complex  POLYMER DEGRADATION AND STABILITY 79 : 195 2003

Cited Reference Count: 24
Times Cited: 0
Publisher: JOHN WILEY & SONS LTD, THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0959-8103 
IDS Number: 221VF

DOI: 10.1002/pi.2271